Please be aware that the 500FG database is temporarily unavailable.
Project | Dataset | Description |
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200FG |
Raw Cytokine Data |
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200FG |
Cytokine QTL Data |
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500FG |
Client Records |
Questionnaire on demographic data, health, gastro-intestinal condition, diet, exercise and smoking. |
500FG | Cytokines |
Several bacterial, fungal and viral stimuli were used in ex-vivo experiments. IFN-y, IL-1b, IL-6 and TNF-a production were measured in whole blood experiments. IFN-y, IL-1b, IL-6, IL-17, IL-22 and TNF-a production were measured in supernatants of PBMC experiments. IL-6 and TNF-a production were measured in supernatants of serum-derived macrophage experiments.
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500FG | Cytokine QTL data (available as zip file) | |
500FG | Thyroid hormones |
Concentration of TSH (mE/l) and fT4 (pmol/l) measured in heparin plasma.
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500FG | Cell staining | cell counts per sample
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500FG | cell staining counts QTL (available as zip file) | |
500FG | Serum Ig levels | Ig levels per sample
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500FG | Metabolome |
Using plasma derived from EDTA blood tubes we measured a whole range of different baseline metabolites. These metabolites can be divided into several sub groups:
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500FG | Platelet activation | Platelet activation was measured on 8 consecutive time points using FACS after stimulation with ADP or Collagen in combination with Pselectin or Fibrinogen.
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500FG | Circulating plasma factors |
Different systemic markers measured at baseline (without stimulation) in either EDTA plasma or serum.
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500FG | Uric acid |
Uric acid levels (mmol/L) were measured systemically at baseline (i.e. without stimulation) in heparin plasma.
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500FG |
Microbiome |
As part of the 500 Functional Genomics (500FG) project, stool samples from 471 healthy adults were subjected to metagenomic shotgun sequencing (one time point per individual). Concurrently, blood samples were collected from each individual and the cytokine production was measured in response to bacterial and fungal stimulations. Significant inter-individual variation was observed in the gut microbial profiles as well as the immunological profiles. Subsequent association testing showed that microbiome-host interactions modulate the inflammatory cytokine production capacity in healthy individuals. |
500FG | Flow cytometry data | Raw flow cytometry data files measured using 4 different 10-color antibody panels (General, T cell, B cell and intracelluar Tcell/Treg panel). |